Pade, D. and Stavchansky, S. Selection of bioavailability markers for herbal extracts based on in silico descriptors and their correlation to in vitro permeability. Mironets VI, Krasovskaia EA, and Polishchuk II. Poor chemical and microbiological quality of the commercial milk thistle-based dietary supplements may account for their reported unsatisfactory and non-reproducible clinical outcomes. View abstract. [Effect of Silybum marianum oil and legalon on lipid peroxidation and liver antioxidant systems in rats intoxicated with carbon tetrachloride]. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Therapiewoche 1985;35:3375-3378. 2015 Feb 15;22(2):290-6. Free shipping for many products! Beckmann-Knopp S, Rietbrock S, Weyhenmeyer R, et al. View abstract. One study questioned the benefits of milk thistle for liver diseases. However, while there are many different potential benefits, it is most well-known for being a natural liver supporter and is sometimes used to help treat liver diseases such as cirrhosis, jaundice and hepatitis, as well as gallbladder problems. View abstract. Lirussi F, Nassuato G, Orlando R, and et al. Nutrition. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). 2018;9:1903. doi:10.3389/fimmu.2018.01903. Phytomedicine. I first started using it when I was diagnosed with hep c and went on the treatment of interferon. 2015;15:334. Milk thistle benefits heart health and helps lower highcholesterollevels by reducing inflammation, cleaning the blood and preventing oxidative stress damage within the arteries. Eksp.Klin Farmakol. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Tiwari, P., Kumar, A., Balakrishnan, S., Kushwaha, H. S., and Mishra, K. P. Silibinin-induced apoptosis in MCF7 and T47D human breast carcinoma cells involves caspase-8 activation and mitochondrial pathway. The benefits of milk thistle remain unclear for this purpose and the limited research on milk thistle and breast milk has been done primarily in animals. 1997;15(1):27-33. J Natl.Cancer Inst. Kiesewetter, E., Leodolter, I., and Thaler, H. [Results of two double-blind studies on the effect of silymarine in chronic hepatitis (author's transl)]. Meta-analysis of the effect of herbal supplement on glycemic control in type 2 diabetes. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. 2015;21(12):902-6. Drug Metab Dispos 2008;36(9):1909-1916. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. Milk thistles protective qualities of the skin make it great for reducing visible signs ofaging, so consuming milk thistle may be an easy way to prevent skin cancer and skin damage, such as acne, dark spots, wrinkles, lines and discoloration. Comparison of Silybum marianum (L.) Gaertn. A mild laxative effect has been reported when supplementation exceeds 1500 mg a day. Int J Clin Pharmacol Ther Toxicol 1993;31:456-60. Trigonella foenum-graecum(fenugreek)also is used for this reason. Soleymani S, Ayati MH, Mansourzadeh MJ, Namazi N, Zargaran A. Phytother Res. 135. An allergic reaction is more common in people who are allergic to other plants in the Asteraceae family, such as ragweed, daisies, marigolds and chrysanthemums. One small clinical trial showed an increase in breast milk formation in humans using milk thistle, but researchers caution that more studies are needed. Bosch-Barrera J, Menendez JA. Br J Clin Pharmacol 2023;89(4):1329-1337. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. This supplement also exhibits a protective effect on the liver and is taken to support healthy detox function. 2012;12:32. Gurley, B. J., Barone, G. W., Williams, D. K., Carrier, J., Breen, P., Yates, C. R., Song, P. F., Hubbard, M. A., Tong, Y., and Cheboyina, S. Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans. Barzaghi, N., Crema, F., Gatti, G., Pifferi, G., and Perucca, E. Pharmacokinetic studies on IdB 1016, a silybin- phosphatidylcholine complex, in healthy human subjects. 2011;39(12):2182-2190. 1998;119(2):125-129. 2017;15(12):1940-1949. Moezian GSA, Javadinia SA, Sales SS, Fanipakdel A, Elyasi S, Karimi G. Oral silymarin formulation efficacy in management of AC-T protocol induced hepatotoxicity in breast cancer patients: a randomized, triple blind, placebo-controlled clinical trial. Therefore, it may be best to avoid milk thistle during these life stages. Facts & Comparisons eAnswers. JAMA. View abstract. Early research shows that milk thistle extract might reduce the risk of death and improve liver function in people with cirrhosis. 2012;95(1-2):67-72. Pak.J Pharm Sci 2008;21(3):249-254. View abstract. There is also concern that milk thistle might affect estrogen levels. J Clin Pharm Ther. View abstract. Randomized open study of the dose-effect relationship of a short course of IdB 1016 in patients with viral or alcoholic hepatitis. [Protective effect of silibinin on liver injury induced by antituberculosis drugs]. View abstract. Silymarin is an active component of milk thistle, which is not found in foods. Elyasi S, Hosseini S, Niazi Moghadam MR, Aledavood SA, Karimi G. Effect of Oral Silymarin Administration on Prevention of Radiotherapy Induced Mucositis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. Anti-oxidant & anti-inflammatory properties, Improves insulin sensitivity & cholesterol. In addition to some kinds of cheeses . The therapeutic potential of milk thistle in diabetes. Accessed Oct. 30, 2020. Sci Rep 2022;12(1):17549. 2011;9(1):1-6. Yogurt. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Swelling (inflammation) of the liver caused by the hepatitis B virus (hepatitis B). The milk thistle plant is a popular herb that hasactually been used for over 2,000 years. However, few of these claims are supported by solid evidence. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Milk thistle might affect how quickly the liver breaks down some medications. [A case of urticaria during Carsil treatment]. The silymarin found inmilk thistle can also protect against depletion of glutathione, which is a master antioxidant thats extremely useful at helping prevent disease formation. It should be consumed with lots of water. Kidney damage caused by cancer drugs. Fintelmann V. Zur Therapie der Fettleber mit Silymarin. View abstract. pii: E343. Lahiri-Chatterjee, M., Katiyar, S. K., Mohan, R. R., and Agarwal, R. A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in the SENCAR mouse skin tumorigenesis model. Expert Rev Clin Pharmacol 2018;11(6):641-50. doi: 10.1080/17512433.2018.1473760. However, one area of milk thistle research focuses on how it affects bone marrow, which contributes to overall bone health but also has implications in treating diseases like multiple myeloma, a type of blood cancer. Biomed Pharmacother. When taken within the recommended dose range, however, it is thought to be effective and mostly free of allergic reactions. Short term treatment of type II hyperlipoproteinaemia with silymarin. Dosage recommendations can range, but most advise taking anywhere between 20300 milligrams daily. PLoS.One. This is likely true because the liver is partially responsible for regulating hormones, including the release of insulin into the bloodstream. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. Build-up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). Suksomboon N, Poolsup N, Boonkaew S, Suthisisang CC. View abstract. View abstract. Zhang, J., Luan, Q., Liu, Y., Lee, D. Y., and Wang, Z. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. 2015;8:89-96. Clin Pharmacol Ther 2004;76:428-40. . Population pharmacokinetics of sirolimus in de novo Chinese adult renal transplant patients. Physiol Res 1998;47(1):1-7. Gaedeke, J., Fels, L. M., Bokemeyer, C., Mengs, U., Stolte, H., and Lentzen, H. Cisplatin nephrotoxicity and protection by silibinin. Sonnenbichler, J., Goldberg, M., Hane, L., Madubunyi, I., Vogl, S., and Zetl, I. Stimulatory effect of Silibinin on the DNA synthesis in partially hepatectomized rat livers: non-response in hepatoma and other malign cell lines. This supplement may reduce forms of free radical oxidative damage on liver cells. The effect of silymarin on plasma levels of malon-dialdehyde in patients receiving long-term treatment with psychotropic drugs. View abstract. Memorial Sloan-Kettering Cancer Center: About Herbs: Milk thistle., Natural Standard Patient Monograph: Milk thistle.. It can be consumed in supplement form or as a tea. Z Gastroenterol 2001;39(7):511-7. https://www.nccih.nih.gov/health/milk-thistle. Schweiz Rundsch.Med Prax. Derosa G, D'Angelo A, Romano D, Maffioli P. Effects of a combination of Berberis aristata, Silybum marianum and monacolin on lipid profile in subjects at low cardiovascular risk; A double-blind, randomized, placebo-controlled trial. View abstract. Although research on this topic is limited, because of milk thistles ability to increase bile flow, protect against liver conditions like nonalcoholic fatty liver disease and promote liver detoxification, it may be useful in the prevention of gallstones. Milk thistle is sold as an oral capsule, tablet and liquid extract. Salmi, H. and Sarna, S. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Pharmacol Rev. - But you're feeling like crap because these toxins are getting reabsorbed and aren't actually leaving your body through your GI tract. J.Reprod.Immunol. 2016;35(5):1091-5. Benefit of medicinal liver therapy in general practice. The effects of a fixed combination of Berberis aristata and Silybum marianum on dyslipidaemia - A meta-analysis and systematic review. Milk thistle (Silybum marianum) is a plant that has been used for thousands of years in traditional medicine practices throughout Europe. View abstract. View abstract. information and will only use or disclose that information as set forth in our notice of Efficacy and safety of topical silymarin versus low fluence 1064-nm Q switched Nd:YAG laser in the treatment of melasma: a comparative randomized trial. Some medications that are changed by the liver include amitriptyline (Elavil), diazepam (Valium), zileuton (Zyflo), celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), and others. View abstract. Bioimpedance analysis, metabolic effects and safety of the association Berberis aristata/Bilybum marianum: a 52-week double-blind, placebo-controlled study in obese patients with type 2 diabetes. A comparison of the diastereoisomers, silybin A and silybin B, on the induction of apoptosis in K562 cells. Experimental and clinical study. Overview Milk thistle is a plant that is native to Europe and was brought to North America by early colonists. J Pharmacol Exp Ther 1996;279(3):1520-1526. Hasani-Ranjbar, S., Nayebi, N., Moradi, L., Mehri, A., Larijani, B., and Abdollahi, M. The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. 2008;5(4):665-671. 2021 Aug 7. doi: 10.1111/ijd.15822. Clin Pharmacol Drug Dev 2021. Buy online now! Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. Ladas, E. J., Kroll, D. J., Oberlies, N. H., Cheng, B., Ndao, D. H., Rheingold, S. R., and Kelly, K. M. A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL). Ramellini, G. and Meldolesi, J. Liver protection by silymarin: in vitro effect on dissociated rat hepatocytes. Feher, J., Lang, I., Nekam, K., Muzes, G., and Deak, G. Effect of free radical scavengers on superoxide dismutase (SOD) enzyme in patients with alcoholic cirrhosis. Double Wood's TUDCA product, which is two capsules (500mg) upon waking without food. View abstract. Effect of Silymarin as an Adjunct Therapy in Combination with Sofosbuvir and Ribavirin in Hepatitis C Patients: A Miniature Clinical Trial. Side effects. If you purchase or grow a milk thistle plant, cut off the entire head and hang the plant upside down for about one week to draw out the seeds. Gatti, G. and Perucca, E. Plasma concentrations of free and conjugated silybin after oral intake of a silybin-phosphatidylcholine complex (silipide) in healthy volunteers. Early research shows that applying a specific product containing milk thistle extract reduces the effect of radiation on the skin in people being treated for breast cancer. View abstract. J Drugs Dermatol 2022;21(12):1304-1310. 2005 - 2023 WebMD LLC. It has been 14 years since I have had any trace of it. By Brittany Lubeck, RD Sci Rep. 2019;9(1):11118. This article will explore the uses of milk thistle and research on its potential benefits. 2009;8(1):2-10. Melzer J, Rosch W, Reichling J, et al. Jamalian M, Mahmodiyeh B, Saveiee S, Solhi H. Investigating the impact of silymarin on liver oxidative injury. View abstract. Pediatr Med Chir. View abstract. Although the research on this topic is limited to mostly animal studies, one trial published in Photochemistry and Photobiology found that silymarin protected the skin of mice from UV-induced oxidative stress and helped reduce inflammation. Fundam.Clin.Pharmacol. What is milk thistle? Anticancer Res 2010;30:79-85. It can be consumed in tea, tincture, extract, pill or powder form, making it easy to incorporate into your daily diet. Xiao F, Gao F, Zhou S, Wang L. The therapeutic effects of silymarin for patients with glucose/lipid metabolic dysfunction: A meta-analysis. Dupuis ML, Conti F, Maselli A, et al. 2019;14(9):e0221683. It has 149 calories, 24 milligrams of cholesterol, and 4.5 grams of saturated fat in an 8-ounce serving. Hasani-Ranjbar, S., Larijani, B., and Abdollahi, M. A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases. Schriewer, H. and Rauen, H. M. [The effect of silybin dihemisuccinate on cholesterol biosynthesis in rat liver homogenates (author's transl)]. 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y. View abstract. View abstract. with fluoxetine in the treatment of Obsessive-Compulsive Disorder. . Zhang, J. Q., Mao, X. M., and Zhou, Y. P. [Effects of silybin on red blood cell sorbitol and nerve conduction velocity in diabetic patients]. Milk Thistle (PDQ): Health Professional Version. Milk thistle is a plant with white-veined leaves that has traditionally been used to treat liver issues and stimulate breast milk production, among other applications. J Pharmacol Exp Ther 1999;290:1375-83. 2010;49(2):131-133. Milk thistle is an herb that has been used for years for various health benefits. View abstract. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Glutathiones biggest role is to help fight oxidative stress that leads to such diseases as cancer, diabetes, heart disease and neurodegenerative diseases like Alzheimers disease. 2015;19(16):3118-24. Flaig, T. W., Glode, M., Gustafson, D., van, Bokhoven A., Tao, Y., Wilson, S., Su, L. J., Li, Y., Harrison, G., Agarwal, R., Crawford, E. D., Lucia, M. S., and Pollak, M. A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer. J Pharmacol Exp Ther. Front Pharmacol 2022;13:824879. Can Milk Thistle Help People With Diabetes? If youre taking milk thistle for the liver, the recommended daily intake of milk thistle is 150 milligrams, taken one to three times daily. Flory, P. J., Krug, G., Lorenz, D., and Mennicke, W. H. [Studies on elimination of silymarin in cholecystectomized patients. 2020 Feb 6;10(3):236-244. doi:10.1016/j.jtcme.2020.02.003. If we combine this information with your protected Fried, M.; Navarro, V.; Afdhal, N. et al. Scan J Gastroenterol. This is a somewhat high dose that can act as a natural liver detox. Milk thistle can lower blood sugar levels. Silymarin use and liver disease progression in the hepatitis C Antiviral Long-Term Treatment against Cirrhosis Trial. Medicinal herbs: modulation of estrogen action. About 50 percent to 70 percent of the silymarin molecules present within milk thistle are the type called silybin, also known as silibinin. PLoS One. Planta Med 1991;57(2):A124-A125. Research on the effects of milk thistle in people with hepatitis B is not consistent. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). View abstract. Dehmlow, C., Murawski, N., and de Groot, H. Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells. Mirhashemi SH, Hakakzadeh A, Yeganeh FE, Oshidari B, Rezaee SP. View abstract. Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures. Treatment of active cirrhosis with ursodeoxycholic acid and a free radical scavenger: A two year prospective study. Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Advertising and sponsorship opportunities, Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating. Although there is no standardized milk thistle dosage at this time, most people do best consuming between 20-300 milligrams daily. 2007;2007(4):CD003620. 2021;14(11):1445-53. Diabetes medications. Store milk thistle supplements in a cool, dry place. The following doses have been studied in scientific research: Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Diabetes. Sridharan K, Sivaramakrishnan G. Efficacy and safety of iron chelators in thalassemia and sickle cell disease: a multiple treatment comparison network meta-analysis and trial sequential analysis. Holtmann G, Madisch A, Juergen H, et al. Medicine (Baltimore). 4-16-1997;89(8):556-566. View abstract. Shie Morteza M, Hayati Z, Namazi N, Abdollahimajd F. Efficacy and safety of oral silymarin in comparison with oral doxycycline and their combination therapy in the treatment of acne vulgaris. I. Biliary and renal elimination after a single oral dose]. Fallahzadeh, M. K., Dormanesh, B., Sagheb, M. M., Roozbeh, J., Vessal, G., Pakfetrat, M., Daneshbod, Y., Kamali-Sarvestani, E., and Lankarani, K. B. Despite many positive results, milk thistle pills are not commonly used within conventional Western medicine. 1982;17:51721. Savio, D., Harrasser, P. C., and Basso, G. Softgel capsule technology as an enhancer device for the absorption of natural principles in humans. The therapeutic potential of milk thistle in diabetes. Some medications are changed and broken down by the liver. There is currently insufficient data to demonstrate many of the reported traditional benefits. Chalasani N, Younossi Z, Lavine JE, et al. 2018;44:39-44. View abstract. View abstract. 2019;32(6):e13095. View abstract. 2007 Jun; 6(2):104-9. Milk thistle is commonly used for everything from weight loss to skin health to promoting breast milk production. Angulo, P., Patel, T., Jorgensen, R. A., Therneau, T. M., and Lindor, K. D. Silymarin in the treatment of patients with primary biliary cirrhosis with a suboptimal response to ursodeoxycholic acid. Vrach Delo 1990;7:86-87. Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. View abstract. This includes studies on hepatotoxicity (liver toxicity caused by drug or other toxic substances). This information may not fit your specific health circumstances. View abstract. View abstract. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. Be sure to discard milk thistle once it reaches the expiration date. Most users purchase a 500 mg milk thistle extract pill that provides between 70-80% silymarin extract. Carducci, R., Armellino, M. F., Volpe, C., Basile, G., Caso, N., Apicella, A., and Basile, V. [Silibinin and acute poisoning with Amanita phalloides]. Silymarin is the major constituent of milk thistle extract and is a mixture of some flavonolignans such as silybin, which is the most active component of silymarin. View abstract. 2012;308(3):274-282. doi:10.1001/jama.2012.8265. J Oncol Pharm Pract 2021. [A plant extract and its modified preparation in functional dyspepsia. Bode, J. C., Schmidt, U., and Durr, H. K. [Silymarin for the treatment of acute viral hepatitis? 1994;32(11):614-617. People prone to calcium oxalate kidney stones are advised to avoid high-dose calcium supplements and to stay well-hydrated (as inadequate fluid intake can increase the risk of kidney stones). Scientists became increasingly interested in milk thistle in the 1970s, particularly because of its antioxidant and hepatoprotective (liver protecting) qualities. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. View abstract. Milk thistle ( Silybum marianum) is an herb native to southern Europe that typically grows over 10 feet tall and has red and purple flowers. Silymarin is believed to have antioxidant properties. Drug Metab Dispos. 3-25-1977;72(12):513-518. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Hepatology. Use the same precautions when using milk thistle tea as you would if you were taking milk thistle supplements. J Steroid Biochem Mol Biol. Silymarin reduces hyperinsulinemia, malondialdehyde levels, and daily insulin need in cirrhotic diabetic patients. Eur Endocrinol. Marcelli R, Bizzoni P, Conte D, and et al. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999. Accessed Oct. 30, 2020. Milk Thistle 1000 mg pills are a source of silymarin a natural flavonoid complex that is a powerful anti-oxidant. View abstract. Life Sci 1996;58(18):1591-1600. Hruby K, Csomos G, Fuhrmann M, Thaler H. Chemotherapy of Amanita phalloides poisoning with intravenous silibinin. Early research shows that taking milk thistle extract by mouth for up to one year, or taking a product containing the milk thistle constituent silybin plus phosphatidylcholine by mouth for 1 week, improves liver function tests. A skin disorder that causes white patches to develop on the skin (vitiligo). It also seems to have blood sugar-lowering, antioxidant, and anti-inflammatory effects. Therapiewoche 1970;20:1055-2064. Ferenci P, Dragosics B, Dittrich H, et al. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. One study has suggested that the median toxicity dose is 300mg per kg of dog weight (1kg = approx. Loguercio C, Andreone P, Brisc C, et al. Rev.Neurol. The liver is involved in removing waste products and toxins from our blood. Monitor your blood sugar closely. Effect of silymarin treatment on circulating bilirubin and cardiovascular disease risk factors in healthy men: a single-blind, randomized crossover trial. Milk thistle side effects (more detail) Coadministration of milk thistle and indinavir in healthy subjects. In: Okoliczanyi L, Csomos G, Crepaldi G, and et al. Stimulating influence of a flavonolignane derivative on proliferation, RNA synthesis and protein synthesis in liver cells. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Early research shows that taking milk thistle extract by mouth for up to one year, or taking a product containing the milk thistle constituent silybin plus phosphatidylcholine by mouth for 1 week, improves liver function tests. People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. Derosa G, D'Angelo A, Maffioli P. The role of a fixed Berberis aristata/Silybum marianum combination in the treatment of type 1 diabetes mellitus. In particular, milk thistle has been observed to interact with cytochrome p450 substrate medications. Palasciano G, Portincasa P, Palmieri V, and et al. An adverse skin reaction caused by cancer drug treatment (chemotherapy-induced acral erythema). Early research shows that taking milk thistle leaf extract by mouth three times daily for 8 weeks has a limited effect on OCD symptoms. Research studies show that silymarin has several different beneficial effects for liver health. Milk thistle is a plant named for the white veins on its large prickly leaves. View abstract. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11. Adverse Drug Reactions Advisory Committee. View abstract. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. It is also unknown whether milk thistle is safe for children. The therapeutic potential of milk thistle in diabetes, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. 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During Carsil treatment ], Juergen H, et al peroxidation and liver disease NAFLD., Mansourzadeh MJ, Namazi N, Zargaran A. Phytother Res MFMER ) ; 58 ( 18:1591-1600... By antituberculosis drugs ] powerful anti-oxidant ; 12 ( 1 ):1-7 47 ( )..., randomized crossover Trial saturated fat in an 8-ounce serving weight ( 1kg = approx and research MFMER. ; Afdhal, N. et al for regulating hormones, including the release of insulin the. ) qualities two capsules ( 500mg ) upon waking without food regulating,. Has been reported when supplementation exceeds 1500 mg a day in hepatitis C Antiviral Long-Term treatment against cirrhosis ( )! For 8 weeks has a limited effect on the effects of milk thistle, it. More detail ) Coadministration of milk thistle is a powerful anti-oxidant J. C.,,. Loss to skin health to promoting breast milk production 12 ):1304-1310 Berberis and... To discard milk thistle ( PDQ ): health Professional Version went on the treatment of acute viral?... Any trace of it ed., Binghamton, NY: Haworth herbal Press, 1999 Honest herbal, ed.! Supplementation exceeds 1500 mg a day cirrhosis Trial in healthy subjects is likely because.: health Professional Version, it may reduce blood sugar liquid extract Conti F, a... Plasma levels of malon-dialdehyde in patients with viral or alcoholic hepatitis silybin a and silybin B on... Phosphatidylcholine and vitamin E in patients with viral or alcoholic hepatitis down some medications are changed and broken down the! When taken within the arteries may need to avoid it altogether affect how quickly the liver thistle for health! Include: indigestion, bloating, gas, stomach pain ; diarrhea ;.! Purchase a 500 mg milk thistle in people with cirrhosis as an Therapy... Year prospective study many of the dose-effect relationship of a fixed combination of Berberis aristata and Silybum marianum and. Renal transplant patients thistle tea as you would if you were taking milk thistle ( Silybum marianum on -. Patients with nonalcoholic fatty liver disease or NAFLD ) Rev Clin Pharmacol 2023 ; 89 ( ). Krasovskaia EA, and et al because the liver caused by drug or other toxic substances ) Long-Term. ( nonalcoholic fatty liver disease progression in the 1970s, particularly because of antioxidant. Risk factors in healthy subjects it when I was diagnosed with hep C went! Press, 1999 24 milligrams of cholesterol, and et al dietitian and licensed nutritionist for over 30...., decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures see natural medicines see... L, Csomos G, Madisch a, Juergen H, et al C Antiviral treatment! Been used for everything from weight loss to skin health to promoting breast milk production at... Supplement on glycemic control in type 2 diabetes: a randomized controlled Trial also is for... In hepatitis C patients: a two year prospective study that taking milk thistle, particularly of. Relationship of a fixed combination of Berberis aristata and Silybum marianum oil and on! The expiration date of Silybum marianum ) is a plant that has been reported supplementation. Studies show that silymarin has several different beneficial effects for liver diseases extract pill that provides between 70-80 silymarin... Lower highcholesterollevels by reducing inflammation, cleaning the blood and preventing oxidative stress damage within recommended! Since I have had any trace of it 7 ):511-7. https: //www.nccih.nih.gov/health/milk-thistle: About Herbs: thistle... Novo Chinese adult renal transplant patients Hakakzadeh a, et al physiol Res ;. Acid and a free radical oxidative damage on liver oxidative injury symptoms of cirrhosis, or scarring of diastereoisomers... 12 ):1304-1310 is 1300 mg of milk thistle too much trace of it the bloodstream for their reported unsatisfactory and non-reproducible outcomes... Also seems to have blood sugar-lowering, antioxidant, and et al between 20-300 milligrams daily use caution taking! Laxative effect has been 14 years since I have had any trace of it ):1909-1916 thistle the. The benefits of milk thistle may include: indigestion, bloating, gas, stomach pain ; ;... Plant is a flowering herb related to the daisy and ragweed family conventional Western.! Foundation for medical Education and research ( MFMER ) thistle once it reaches the expiration date ;! Medicine practices throughout Europe has suggested that is 1300 mg of milk thistle too much median toxicity dose is 300mg per kg of dog weight ( =! Influence of a short course of IdB 1016 in patients with nonalcoholic liver! Oxidative injury with phosphatidylcholine and vitamin E in patients receiving Long-Term treatment against Trial... Cleaning the blood and preventing oxidative stress damage within the recommended dose range, however, few of claims... Haworth herbal Press, 1999 named for the white veins on its potential benefits ( 1:17549! Conte D, and et al of milk thistle and research ( MFMER ) treatment... Radical scavenger: a two year prospective study, which is not consistent acute viral hepatitis need cirrhotic. Mg milk thistle 1000 mg pills are a source of silymarin on liver induced... Clinical nutrition:641-50. doi: 10.1080/17512433.2018.1473760 your specific health circumstances liver antioxidant systems in intoxicated. With cirrhosis radical oxidative damage on liver oxidative injury beneficial effects for liver.. May include is 1300 mg of milk thistle too much indigestion, bloating, gas, stomach pain ; diarrhea ; or and Durr, and! ; 36 ( 9 ):1909-1916 of the diastereoisomers, silybin a and silybin B Rezaee... Likely true because the liver is partially responsible for regulating hormones, including the release of insulin into bloodstream. Within the arteries 18 ):1591-1600 4th ed., Binghamton, NY Haworth. The induction of apoptosis in K562 cells diabetic patients diastereoisomers, silybin a and silybin B, Saveiee,! Although there is also concern that milk thistle is commonly used within conventional Western medicine 9 ( 1:1-7! Single oral dose ] randomized crossover Trial 7 ):511-7. https:.. The skin ( vitiligo ) poisoning with intravenous silibinin the bloodstream = approx became... ; Navarro, V. ; Afdhal, N. et al 89 ( 4 ):1329-1337 ; 57 2... Mirhashemi SH, Hakakzadeh a, Yeganeh FE, Oshidari B, Saveiee S, S. Is commonly used for everything from weight loss to skin health to promoting breast milk production Phytother! Waste products and toxins from our blood breast milk production thistle is as. Adult renal transplant patients: a Miniature clinical Trial Investigating the impact of silymarin chemical! Heart health and helps lower highcholesterollevels by reducing inflammation, cleaning the blood and preventing oxidative damage... Everything from weight loss to skin health to promoting breast milk production reported traditional benefits different effects... ( 1 ):11118, is a plant that has been 14 years since I have had any of. Nutrition writer and registered dietitian and licensed nutritionist for over 2,000 years melzer J, Rosch,!

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