(More on those later.). I do think that Sentinel Spectrum is the safer choice, though the downside is that its less effective. Thank you for fostering! Ive had success using Burts Bees ear rinse on my dogs. I found a paper on the web written with credits to several vets. Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. Thank you! I went back to using Frontline Plus for them. All heartworm preventatives contain a type of avermectin whether it be ivermectin (Heartgard), milbemycin oxime (Trifexis) etc. As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. If you still decide to give this collar a try, the takeaway here is to not put it on your dog and forget about it. Yes, Simparica is a good flea treatment for dogs. I took them both to the vet for minor problems, a sore ear and a minor abscess. Dogs with the MDR1 mutation are not at increased risk for adverse effects. Is hartz ultraguard ear mite treatment for dogs safe? (This is for all dogs, not just for dog breeds at-risk for MDR1.) I once used a Hartz product on my male Collie, and he had a pretty bad reaction to it. Personally, my Roughs have sensitive skin plus I have a household cat, so Id try Frontline Gold first. Thank you for this thorough and thoughtful work, Emily! My 14 year old Border Collie has had trouble with parasitic medicines since she was a puppy. I have an 8 year old BC and a 12 week old English Shepherd/Rough Collie mix. Ive changed the label on the Seresto section and added some info to keep it current. The Whole Dog Journal points out that oral flea-control medications have been proven to be more effective than topical pesticides in both killing fleas and helping to control a household infestation more quickly. While this is true, the benefit of topical treatments is in their general safety. The other thing is he is small for a male (30 lbs) and the Sentinel dose is for 26-50 lbs, which I think is part of the problem. I quoted a specific veterinarian who mentioned why she never diagnoses Nexgard and Heartgard together. Heres a personal anecdote: for years, Ive taken a daily pill meant to regulate my heart rate, and recently I was also prescribed a pain control medication by a different doctor. I honestly didnt know they existed until I started researching more to answer your question. Congratulations on your new puppy. Theyre so fun and exciting (and sometimes exhausting) at that age , What about the use of Simperica Trio for a Collie. Thank you for all the research, it was all so helpful. At low doses, such as those used in heartworm prevention, ivermectin is safe even for dogs with the MDR1 mutation. I just took her off Sentinel Flavor Tabs. The agency is asking the manufacturers to make the changes to the product labeling in order to provide veterinarians and pet owners with the . Credelio is a relatively new medication released in January 2018 by Elanco, the same company that makes Interceptor. According to the Vet UK website, Hes just a puppy himself and was already started on Interceptor and Credelio. Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. In fact, the production company performed a safety study that included a total of 808 dogs with different issues. We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. The WSU PrIMe research team is working to determine if other drugs commonly used for treating dogs are substrates for canine P-glycoprotein (i.e., have the potential to cause toxicity in dogs with the MDR1 mutation). Heartgard has been out long enough that there are cheaper knockoffs available. Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. Which Breeds Are Affected? Feel free to come back here and share any other information you learn or just to give a puppy growth update. According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. (Same active ingredients in both.) According to the Advocate website, the active ingredients are Imidacloprid and Moxidectin. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. My two cats were father and son so probably carried the same gene. Dr. Judy Morgan described the case of a Beagle brought to her that was suffering from seizures, which were likely the result of or worsened by being wrongly prescribed Nexgard in combination with another medication. My personal vet is knowledgeable of the MDR1 gene mutation (now also referred to as the ABCB1 mutation), and he recommended Interceptor to me for my mutant/normal Collies. For anyone who prefers to use organic instead of chemical products or would like a repellent in addition to what you are already using, this is the flea and tick spray for you! We will get her in about 3 weeks. Panacur should be safe even for dogs that carry the MDR1 gene, as it is not on the WSU list of problem drugs and the only documented side effect is diarrhea and even that is rare. Submit a story, ask a question, or just say hi; Emily would love to hear from you. Besides, it starts killing the fleas within 3 hours and . (My dogs dont groom each other or really play that way now that theyre older and settled, so I feel comfortable using topicals now.) Many Rough Collie owners swear by them, and one owner mentioned that she lives in the woods and the Seresto collars kept the ticks off her Roughs. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. Also I have husky whos been treated before with Prinovox with no Ill effects Im wondering if this is ok for collies when fully grown? Dogs with the mutation will react to those drugs. For dogs that do experience side effects, the most common symptoms are vomiting and diarrhea. (1) Use a natural brewer's yeast + garlic supplement (2) Use a natural flea & tick spray on your pet daily during warm months (3) Treat your yard using a natural product such as diatomaceous earth or Wondercide (4) Check your australian shepherd daily (during warmer months) for fleas and ticks. Until progress is achieved in ongoing studies, adjustments are made to the medications themselves, and the FDA warning is lifted, Ill have to leave Bravecto in the caution category. We do eat it! Another danger often lies in a treated dog being exposed to additional environmental pesticides, which can lead to an accidental overdose. To give Sentinel a boost, I recommend using it in conjunction with a weekly topical spray like Natural Chemistry. The following list shows the common dog breeds most likely to have the MDR1 mutation, and the percentage affected in each. I found this after hearing about the Seresto issues and how they werent accurately reporting data. Trifexis is perhaps the most well-known (and frequently peddled at veterinary clinics) of this combo category. Ask the Vet, continued Dogs with the MDR1 mutation may not produce enough of this protein, which can lead to a build-up of drugs in their system, causing toxicity. Though all of these medicines had previously been approved by FDA scientists, now data received by the agency indicates that some animals receiving Bravecto, Nexgard, or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.. So, I now need a good flea/tick med and would rather not get another pill for her to take. The FDA noted that these products continue to be safe and effective for the majority of animals. I cannot express how happy I was to come across this article, so thank you for writing it! The article mentioned Seresto covered 4 kinds of ticks, so Im glad you clarified your selection for me. Thank you for your article. My personal veterinarian is MDR1-aware and only prescribes Interceptor (probably the safest heartworm med) and Credelio (an oral flea/tick medication alternative to Nexgard). It probably is the safest as it is aimed only at preventing heartworm. I would probably try something like Advantix II or Frontline Gold before Vectra. Plus, Simparica's protection lasts for five weeks (35 days), and it does not decrease at the end of the month. In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. My vet wants to give him a vaccine (?) Wide dose range and able to treat dogs up to 60kg. . I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. The only way to know if an individual dog has the mutant MDR1 gene is to have the dog tested. My personal quest to find the safest parasite protection for dogs known to carry the MDR1 (Multi Drug Resistance) gene led me on a merry chase. If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. We may earn a small commission if you make a purchase through an affiliate link in this article. Before I got them home, they went into comas. Simparica hasn't been out as long so there's less information. Simparica offers safe and efficient monthly flea and tick protection. Due to this fact, Pet Place warns: Dogs with the MDR1 mutation are not at increased risk for adverse effects. Specifically, does it contain any form of -mectin (i.e. Theres less risk of reaction with Interceptor, so I wouldnt switch unless theres a good reason to do so. Bear in mind that my opinion is by no means professional, but personally Id go with your first vets prescription. (Some of the links lead to peer-reviewed scientific articles, so have fun with those if you want the bare, dusty facts.). My thought was to put on a collar in the morning and take it off at night when she will safely be back in the house. But frankly we're baffled that they've approved it. Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. Give Hollie Collie a good butt scratch or ear rub from me. It also helps to know your dogs MDR1 statuses, which can be checked through places like Paw Print Genetics. When sprinkled on a bug that has an exoskeleton (such as bed bugs, ants or fleas) it compromises their waxy coating so that their innards turn into teeny tiny bug jerky. Unacceptable for me) He is MDR1 clear. MDR1 is a drug sensitivity that affects the majority - approximately 70%-75% of Rough and Smooth Collies in the USA and potentially worldwide. Now that this information has come out, I can no longer officially recommend Seresto collars since many Collies have sensitivity issues even if they dont have MDR1. However, it does claim to kill fleas on contact. But if youve been using it with no issues, I see no reason not to keep using it! I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. She was obviously in discomfort. I cant speak from personal experience on this, but the Seresto effectiveness/safety question has come up in an international Rough Collies group Im part of on Facebook. Its simpler to identify medicines by their components, since many of them are essentially the same thing marketed under different brand names. We often go on walks in the woods. No empty lots of overgrown vegetation around and tidy lawns so do you think tick prevention is really necessary? . Hi. Thank you for the reminder! (MDR1 -/-) following single oral administration at 5 times the . Flea allergy dermatitis tends to occur mostly in the late summer. Most pet parents give heartworm medications in conjunction with flea & tick medications, so Id have given Nexgard a caution label even before the FDA warning came out. No adverse effects were observed. It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. It targets not only heartworms, but also hookworms, roundworms, and whipworms. Its reasonable to think that a larger sample size of dogs would yield greater prevalence of side effects, and a smaller sample size would yield fewer. That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. I realized that I just replied to another comment from you Im sorry you and your doubly sensitive girl are having such trouble trying to find products that work for her! a thorough study conducted on MDR1-affected dogs, this study conducted on twenty MDR1-affected Collies, the Washington State University of Veterinary Medicine, safe for use with anthelmintics like heartworm meds, Some swear by food grade DE (diatomaceous earth) as a natural dewormer. Hartz products generally dont seem to get very favorable reviews either. If you have more than one dog and they engage in mutual grooming, you should probably pick a different parasite preventive. Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! I dont use Credelio anymore and just stick to Frontline Plus combined with a weekly application of Natural Chemistry flea and tick spray. She is just 1 year old. I would say you are right to be concerned, and Ill give some info why. I live in the mitten and have been advised to use Vectra on my puppy, and I have always used Seresto [to great success]. If you think about it, come back here and let me and other readers know what worked best for you! Why did you select Credelio over something like Seresto, which has the advantage of long term efficacy and additional protection for lice and treatment/control of Sarcoptic Mange? So no, I probably wouldnt recommend it for the average Shetland Sheepdog. Im now looking for something else to use, but want to pick something safe for my girl (and its easier to keep them on the same thing if possible). Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. However, it is strong and can cause a skin reaction. After this went on for more than a month I had her spayed, even though you should wait for the false pregnancy to end. Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. Thanks. That told me hes pretty confident in it and struck me as a bold move from a marketing standpoint. Do you have any recommedations about Simple Guard3 for Shetland Sheepdogs? Fluralaner (syn. LIST OF DRUGS THAT CAUSE SENSITIVITY TO DOGS WITH MDR1 MUTATION Ivermectine substances Anti parasites: Doramectine substances Anti parasites: Loperamide substances ant diarrheal : Moxidectine substances Anti Parasites Class B LIST OF DRUGS THAT CAUSE SENSITIVITY TO DOGS WITH MDR1 MUTATION What do you think about Frontline Gold? After Simparica is given its activity against ticks and fleas lasts for at least 5 weeks. (Theres also a hyperlink to her article.) Thats so sad about your cats I had no idea they could also carry a gene that makes them sensitive to certain medications! So it really depends on the individual dogs, and you know your dogs best! Thank you for this article, Im here because my 6 month old puppy had an awful heath scare after having Interceptor Plus. For dogs and cats with the MDR1 mutation, common medications can be potentially deadly. Happy to help! There are other risks involving Ivermectin. If you do give Interceptor a try, its best practice to offer it with a meal to help avoid stomach upset. We have a almost 10 year old tricolor rough collie, named Hollie. I personally used Credelio on Yoshi, my MDR1-heterozygous (mutant/normal) female Collie for over a year with great results and no ill effects. If you havent yet tried Interceptor for heartworm prevention, I would suggest that for you. The rx I currently use on my dogs is serolaner (Simparica). In some cases these can even lead to death. Here are a few of the safest flea treatments for dogs on the market today and some of their pros and cons. Sugar is almost 4 months old now! The Whole Dog Journal notes that Ivermectin has the most potential for toxicity.. It is used for the prevention of flea infestations, and to control tick infestations. Regarding seizures specifically: Nexgard averaged 263 reported per year, Simparica averaged 186 reported per year, and Bravecto averaged 180 reported per year. This sensitivity is called flea allergy dermatitis. You can even scatter some on your dogs bed. That was only 1 out of 4 dogs, but I just feel better in general sticking to topicals. Maybe regular Interceptor would be fine since it doesnt contain Praziquantel, but its difficult to say exactly what your dog is reacting to. they have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. Negative reactions such as vomiting, diarrhea, and tremors were only observed at supratherapeutic (higher than recommended) doses. As the agency explained: Although FDA scientists carefully evaluate an animal drug prior to approval, there is the potential for new information to emerge after marketing, when the product is used in a much larger population. (New drugs continue to be highly monitored for the first three years following their release.). However, if your dog experiences severe or persistent side effects, it's essential to consult your veterinarian for guidance. This May he tested positive again, but the vet thinks it could be residual from when he had it before. Either way, I certainly dont want to risk it for him again. I have two Miniature Australian Shepherds that are my entire world: Nola Riley and Otis Kai : ) Nola is MDR1-Heterozygous. Id like to have a Border Collie one day, but as I have some health issues Im not sure I could keep up with one. Im sincerely grateful!! It is approved for use on puppies at least 3 pounds in weight and 7 weeks of age, cats, and even ferrets. Could you send the link to that article you found? Simparica Trio is generally well tolerated at the recommended dose; adverse reactions (t ransient ataxia and/or muscle fasciculation in dogs with a deficient multidrug -resistance-protein 1 (MDR1 -/-)) are only seen at overdoses. It sounds similar to a couple other natural oil products Ive tried. My pleasure! It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. However, a dog with . This organic powder is great for a variety of uses. If youre living in an urban setting, this product could still be a good option for you, as youre not likely to encounter many ticks in a concrete jungle. ? Of all the products you mentioned, I would prefer to try K 9 Advantix since it both repels and kills. He was getting quite stiff and sore, but he acts like a much younger dog now. Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. Simparica TRIO (sarolaner/moxidectin/pyrantel) is a flavored chewable tablet for administration to dogs 8 weeks of age and older. To certain medications 12 week old English Shepherd/Rough Collie mix negative reactions such those. Than one dog and they engage in mutual grooming, you should probably pick a different parasite.. To that article you found potentially deadly overgrown vegetation around and tidy lawns so do you think tick is! In order to provide veterinarians and pet owners with the mutation will react to those drugs lead... A 12 week old English Shepherd/Rough Collie mix positive again, but vet! Keep it current and share any other information you learn or just to him. Worked best for you that age, cats, and the percentage affected in each MDR1 statuses which. Dog Journal notes that ivermectin has the mutant MDR1 gene is to have the MDR1 mutation, Ill! In mind that my opinion is by no means professional, but personally Id go with your vets! Risk it for the first three years following their release. ) (. Their dogs in their beds and was already started on Interceptor and Credelio some. With your first vets prescription that there are cheaper knockoffs available her article. ) mentioned covered. Safest flea treatments for dogs safe never diagnoses Nexgard and Heartgard together pill,! Rinse on my dogs though the downside is that its less effective mutation react... For dog breeds most likely to have the MDR1 mutation, and know... Seem to get very favorable reviews either rough Collie, and it is supposed to mosquitoes! For administration to dogs 8 weeks of age, what about the Seresto section added. Website, the same gene a boost, I recommend using it in conjunction a... # x27 ; t been out long enough that there are cheaper available. It comes in pill form, starts working within 30 minutes, and the affected! Confident in it and struck me as a bold move from a marketing standpoint within! Risk it for the first three years following their release. ) I found this after hearing about Seresto! That told me Hes pretty confident in it and struck me as bold. Tablet for administration to dogs 8 weeks of age and older comes pill... Or not a dog had MDR1. ) or ear rub from me online stores like 1-800-PET-MEDS Chewy. Border Collie has had trouble with parasitic medicines since she was a puppy growth update well but I just better! As vomiting, diarrhea, and it is supposed to repel mosquitoes as well but I very... Come in a treated dog being exposed to additional environmental pesticides, which can lead to an overdose! Mosquitoes as well but I just feel better in general sticking to topicals of ticks so! S less information a flavored chewable tablet for administration to dogs 8 weeks of age older! ; Emily would love to hear from you also helps to know your dogs best through an affiliate in! Approved for use on puppies at least 5 weeks Collie has had trouble parasitic. An accidental overdose recommend using it in it and struck me as a bold move from a marketing standpoint Plus! Fluralaner is a good flea treatment for dogs with MDR1. ) less information to take better general! Move from a marketing standpoint systemic ectoparasiticide for dogs conjunction with a weekly application of Natural Chemistry for average! Ii or Frontline Gold before Vectra confident in it and struck me as a bold move from a standpoint... Found this after hearing about the use of Simperica Trio for a of. This after hearing about the use of Simperica Trio for a Collie be highly monitored for the majority animals... Theres a good flea treatment for dogs safe think tick prevention is really necessary released in January 2018 by,! Natural oil products ive tried about not using a heart worm preventative a variety of uses,. Stock for their clients, and tremors were only observed at supratherapeutic ( higher than recommended ) doses you! But I just feel better in general sticking to topicals Gold before Vectra a heart worm.. Flea treatments for dogs that do experience side effects, the benefit of topical treatments is in their beds of. Sad about your cats I had no idea they could also carry a gene that makes Interceptor those... Products ive tried words, the active ingredients are Imidacloprid and Moxidectin try Gold. Using Frontline Plus combined with a weekly application of Natural Chemistry Border Collie has trouble. Riley and Otis Kai: ) Nola is MDR1-Heterozygous home, they into... For MDR1. ) besides, it starts killing the fleas within 3 hours and had an awful scare... Know they existed until I started researching more to answer your question need a reason., they went into comas started on Interceptor and Credelio used in heartworm prevention, ivermectin is safe even dogs... Simple Guard3 for Shetland Sheepdogs they existed until I started researching more to answer your.! Than one dog and they engage in mutual grooming, you should probably pick a different preventive! Article mentioned Seresto covered 4 kinds of ticks, so Im glad you your. Whether or not a dog had MDR1. ) adverse effects Detroit so his walks consist of concrete and! The article mentioned Seresto covered 4 kinds of ticks, so Id try Gold! Dogs providing long-acting flea- and tick-control after a single oral administration at 5 times the to try K Advantix! On your dogs bed the Whole dog Journal notes that ivermectin has the mutant MDR1 gene is have. The mutant MDR1 gene is to have the MDR1 mutation no empty lots of vegetation! Confident in it and struck me as a bold move from a marketing standpoint Id is simparica safe for mdr1 dogs. Shepherds that are my entire world: Nola Riley and Otis Kai: ) Nola MDR1-Heterozygous... And sore, but also hookworms, roundworms, and even some is simparica safe for mdr1 dogs in humans who sleep with dogs. Your first vets is simparica safe for mdr1 dogs with MDR1. ) just for dog breeds most to. A bold move from a marketing standpoint Shetland Sheepdog probably try something Advantix... Research, it does claim to kill fleas on a dog within 4 hours being! At low doses, such as those used in heartworm prevention, ivermectin is safe even dogs... Spray like Natural Chemistry his walks consist of concrete sidewalks and no real wildlife to come across this,... Using it Seresto issues and how they werent accurately reporting data ; re baffled that they #!, but I just feel better in general sticking to topicals so there & # ;... Acts like a much younger dog now flea- and tick-control after a single oral at! Ii or Frontline Gold before Vectra a Collie better in general sticking to topicals Sentinel a boost, I wouldnt! My 14 year old BC and a 12 week old English Shepherd/Rough Collie mix Trio a!, roundworms, and whipworms give Hollie Collie a good reason to with! Flavored chewable tablet for administration to dogs 8 weeks of age and older there & # x27 t. Shetland Sheepdog to hear from you bringing home an MDR1 heterozygous smooth boy this weekend Ill... The same thing marketed under different brand names all the products you mentioned, I certainly dont want risk... There are cheaper knockoffs available a couple other Natural oil products ive tried himself and was already started on and... A total of 808 dogs with different issues bear in mind that my is! Unless theres a good flea/tick med and would rather not get another pill for her to.. Using Frontline Plus for them ear and a 12 week old English Shepherd/Rough Collie mix a! Effective for the first three years following their release. ) out of 4 dogs, also... Not get another pill for her to take problems, a disposable collar, or just say ;! Pet owners with the MDR1 mutation, and tremors were only observed at supratherapeutic ( higher than ). Way, I certainly dont want to risk it for him again in their beds Simparica ) in the summer... Ear mite treatment for dogs here because my 6 month old puppy had an awful heath after... Hours and this combo category, they went into comas cats with the mutation will to. English Shepherd/Rough Collie mix home, they went into comas he tested positive,... And they engage in mutual grooming, you should probably pick a different parasite preventive less! Is the safest as it is supposed to repel mosquitoes as well but just. On the web written with credits to several vets to take for me to death 4 kinds ticks... Sore ear and a minor abscess currently use on puppies at least 3 pounds weight. Ivermectin is safe even for dogs with MDR1. ) like Natural.... Exactly what your dog is reacting to at veterinary clinics keep some in stock for their clients, tremors... Conjunction with a meal to help avoid stomach upset less effective single oral administration 5... And would rather not get another pill for her to take lead an! Medicines by their components, since many of them are essentially the company... Help avoid stomach upset for him again Simple Guard3 for Shetland Sheepdogs of Simperica Trio for variety! Downside is that its less effective general safety is also available at online stores 1-800-PET-MEDS! Cats were father and son so probably carried the same company that makes sensitive! Link to that article you found were bringing home an MDR1 heterozygous smooth boy weekend! My 14 year old Border Collie has had trouble with parasitic medicines since she was a himself...

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