27 – 29 These nontraditional delivery methods also avoid the presystemic metabolism of oxybutynin and consequently reduce the plasma concentration of DEO. Typical drugs. It also impacts learning and memory. -agitation. Common side effects of oxybutynin. Side effects such as dry mouth, constipation, and confusion may be more likely in older adults. Differential effects of the antimuscarinic agents darifenacin and oxybutynin ER on memory in older subjects. Contents of the pack and other information . Learn about Ditropan (Oxybutynin Tablets) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. Oxybutynin and memory loss. Background and objective: Oxybutynin is a common antimuscarinic therapy for overactive bladder. Antimuscarinic effects more pronounced when taken with other drugs with the same effects, such as tricyclic antidepressants. Extended Release Oral Tablet. you should know that oxybutynin may make it harder for your body to cool down when it gets very hot. cells. Learn about side effects, warnings, dosage, and more. decreased appetite. The more common side effects that can occur with oxybutynin include: being unable to urinate. The drugs work by activating signaling pathways for dopamine — a chemical messenger involved in many brain functions, including motivation, pleasure, motor control, learning and memory. Major side effects can include memory loss, confusion, delusions, hallucinations, drowsiness and compulsive behaviors such as overeating. 4. It comes in two oral tablet forms: oral tablet and oral disintegrating tablet (ODT). This medicine reduces the amount of bathroom visits. Although tolterodine (Detrol) has fewer side effects than oxybutynin, it is slightly less effective. In the brain, acetylcholine is involved in learning and memory whereas in the rest of the body, it stimulates muscle contractions. Oral Solution. Ingestion of 100 mg oxybutynin chloride in association with alcohol has been reported in a 13-year-old boy who experienced memory loss, and a 34-year-old woman who developed stupor, followed by disorientation and agitation on awakening, dilated pupils, dry skin, cardiac arrhythmia, and retention of urine. How they can cause memory loss: These meds activate signaling pathways for dopamine, a chemical messenger involved in many brain functions, including motivation, the experience of pleasure, fine motor control, learning and memory. Lyrinel XL contains a medicine called Oxybutynin which relaxes the muscles of the bladder, causing the bladder wall to contract less quickly. The more medicines a person takes that have anticholinergic activity the greater the risk of side effects such as memory problems, as this reader discovered: Q. … arthritis. Donepezil is a prescription drug. Donepezil oral tablet is … A close relationship exists between central cholinergic activity and information processing in the brain. It is usually applied twice each week (every 3–4 days). Oxybutynin. Paroxetine potently inhibits CYP2D6 and dextromethorphan is a sensitive CYP2D6 substrate. Side effects that you should report to your doctor or health care professional as soon as possible: -allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue. Oxybutynin is prescribed for problems caused by an overactive bladder, such as urinary incontinence and enuresis. Continue to take transdermal oxybutynin even if you feel well. 5 Drugs that are more likely to cross the blood brain barrier are small (<400kDa), lipophilic, hydrophobic and have a neutral charge. Patients and methods: In a randomized, double-blind, multicentre trial, 95 patients with spinal cord injuries and detrusor hyper-reflexia were studied. hallucinations. “Oxybutynin is the least expensive antimuscarinic drug available, but its pharmacologic properties may cause significant cognitive side effects in elderly persons,” Pucheril said in a statement. oxybutynin decreases levels of risperidone by inhibition of GI absorption. You should apply transdermal oxybutynin on the same 2 days of the week every week. constipation. Consumer; Professional; In Summary. Eur Urol 2006; 50: 317–326 2. In addition, the following adverse events were reported by 1 to < 5% of patients using Oxybutynin chloride (5 to 20 mg/day) in all studies. … In addition, the following adverse events were reported by 1 to < 5% of patients using Oxybutynin chloride (5 to 20 mg/day) in all studies. Stop using this medicine and seek medical attention right away if you or your child have any of the following symptoms: Frequent, urgent, or painful urination. CNS Effects: agitation, confusion, hallucinations, abnormal behavior & memory impairment. Call your doctor for medical advice about side effects. for studying the potential physiological and ethological side effects of oxybutynin, including its effects on memory, social relationships and sensory perception. Depending on which forum you're on they will either suggest addressing emotional issues or making healthy lifestyle changes. It counteracts the effects of most memory medications. You may report side effects to FDA at 1-800-FDA-1088. Where should I keep my medicine? Fever. You may report side effects to FDA at 1-800-FDA-1088. Galantamine comes as a tablet, an extended-release (long-acting) capsule, and a solution (liquid) to take by mouth. It is on the World Health … Weight loss is found among people who take Oxybutynin, especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years. The phase IV clinical study analyzes which people take Oxybutynin and have Weight loss. It is created by eHealthMe based on reports of 16,294 people who have side effects when taking Oxybutynin from the FDA, and is updated regularly. The results of this study add considerably to our knowledge regarding the differential effects of two antimuscarinics, darifenacin and oxybutynin ER, on memory. sweating less than usual (raises your risk of overheating, having a fever, or getting heat stroke if you're in warm or hot temperatures) trouble sleeping. Evaluate Your Treatment. The immediate-release oral tablet is … Commonly reported side effects of oxybutynin include: constipation, drowsiness, and local pruritus.Other side effects include: urinary tract infection, blurred vision, dizziness, dyspepsia, headache, nausea, rhinitis, and xerophthalmia. When used in combination with alcohol and other sedating drugs, the effects can be very powerful and lead to excessive sedation, drowsiness and dizziness. Objective: To compare tolterodine with oxybutynin in treatment of urge incontinence. This is not a complete list of side effects and others may occur. These common side effects of oxybutynin may affect more than 1 in 100 people: dry mouth. Study design: A systematic review, following Cochrane methods, was performed to retrieve results of randomized trials that compared tolterodine with oxybutynin in adults with urge incontinence. Here below, Read the entire detailed patient monograph for Ditropan (Oxybutynin Tablets) They are both beta-3 agonists used for OAB that help your bladder relax so it can hold more urine. memory loss. Sleep. What Oxybutynin is and what it is used for . They also both cause less drowsiness and memory loss than anticholinergic medications for OAB like oxybutynin, because they don't reach the brain.Gemtesa (vibegron), however, is newer than … The tablets and syrup are usually taken two to four times a day. Memory impairment Profound restlessness & disorientation, agitation Hallucinations, delirium Ataxia, muscle twitching, hyperreflexia, seizures Exacerbation of cognitive impairment (in patients with dementia) Tips to Deal with Anticholinergic Side-Effects . Pharmacokinetics, metabolism, and saliva output during transdermal and extended- we made our work being unaware of its possible adverse effects. It may also help to control wetting accidents. Where should I keep my medicine? Side effects that you should report to your doctor or health care professional as soon as possible: -allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue. What is in this leaflet: 1. Helps you to have better control over OAB symptoms such as urgency, frequency, and leakage . 4 The two groups are … Studies Designed to Assess Specific CNS Effects. 14 A pharmacokinetic study revealed that oxybutynin was rapidly absorbed, and peak concentrations were reached within about 1 hour of administration, measured at 8.2 ngml-1 and AUC was 16 ngml-1. Druginformer Identified Side Effects: Dry mouth, Loss of libido. Save up to 80% on Oxybutynin Chloride ER with a free BuzzRx coupon, accepted at over 60,000 pharmacies nationwide. constipation, drowsiness, and local pruritus. List of PDF Full Texts available from EurekaMag Chapter 71622 Chapter 71622 contains a list of PDF Full Texts available from EurekaMag. The incidence of dry mouth was dose-related. You may report side effects to FDA at 1-800-FDA-1088. Absorption. It can present for the first time when a sedative medicine is given to help a patient with dementia normalise their sleep/wake pattern because they don’t wake to pass urine. puffy face from water retention. -confusion. If symptoms of angioedema occur, discontinue DITROPAN XL ® immediately and initiate appropriate therapy. we made our work being unaware of its possible adverse effects. Common side effects of Ditropan XL include dry mouth, constipation, tiredness, headache, diarrhea, urinary tract infection (UTIs), blurred vision, difficulty urinating, and local reactions at the application site such as itching and rash with transdermal … It is created by eHealthMe based on reports of 7,814 people who have side effects when taking Oxybutynin chloride from the FDA, and is updated regularly. This allows the bladder to store more urine without feeling the need to urinate. Alcohol can make the side effects from oxybutynin worse. In some cases, however, the patient may not adequately respond to the treatment, or the anticholinergic adverse effects may be unacceptable to the patient. Monitor for dextromethorphan-related side effects, such as drowsiness, nausea or vomiting, sweating, restlessness, or tremor. Call your doctor for medical advice about side effects. I definitely had some weird brain fog and forgetfulness while on oxybutynin (but I was on some other meds as well at the time). 6. Oxybutynin chloride is an antispasmodic, anticholinergic agent. Which Benzo is best for elderly? 3. The findings suggest that oxybutynin ER significantly impairs memory. Oral Tablet. The phase IV clinical study analyzes which people take Oxybutynin and have Memory loss. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). The goal of the study was to compare the memory loss effects of darifenacin and oxybutynin in older, healthy patients. This generic drug is in the therapeutic class of Bladder and Prostate Health with generic name alternatives including Oxybutynin Chloride ER.For the most common version of Oxybutynin Chloride ER, the average retail price is $93.10, but you could pay as … I didn’t stay on it super long due to other side effects. dizziness. ditropan. 5 The anticholinergics used for OAB are either tertiary or quaternary amines. 1. Objective: To compare trospium chloride (TCl), a quaternary ammonium derivative with atropine-like effects and predominantly antispasmodic activity, with oxybutynin (Oxy) in terms of efficacy and adverse effects. Call your doctor for medical advice about side effects. Drugs that are more selective for M3 receptor (Solifenacin, Darifenacin, & Fesoterodine) have CNS side effects than the older, non-selective drugs (oxybutynin). Oxybutynin is the least expensive antimuscarinic drug available, but its pharmacologic properties may cause significant cognitive side effects in elderly persons. Read the entire detailed patient monograph for Ditropan (Oxybutynin Tablets) The phase IV clinical study analyzes which people take Oxybutynin chloride and have Memory loss. The phase IV clinical study analyzes which people take Oxybutynin chloride and have Dementia. ” The tablets and liquid are usually taken twice a day, preferably with the morning and evening meals. Furthermore, Zinner reported no CNS side effects in a phase 3 trial of trospium. Oxybutynin and memory loss. Cognitive side effects occur if the drug can cross the blood brain barrier into the central nervous system. in patients taking 5 mg oxybutynin for more than 3 years compared to no use (Thomas & Walters, 2021): the estimated Walmart cost for generic oxybutynin is ~$9 for a supply of 30 generic tablets ( GoodRx.com; 7/23/2021). In contrast, no such impairment was seen with darifenacin in the three studies which investigated this agent. Given for urinary frequency 5 The anticholinergics used for OAB are either tertiary or quaternary amines. Side effects of these medicines can include drowsiness, dry mouth, constipation, and anxiety. Keep out of the reach of children. Side effects requiring immediate medical attentionClumsiness or unsteadinessconfusionconvulsionsdizzinessdrowsiness (severe)faintingfast, slow, or irregular heartbeatfeverflushing or redness of the facehallucinations (seeing, hearing, or feeling things that are not there)More items... OXYBUTYNIN (ox i BYOO ti nin) is used to treat overactive bladder. Prescription medications ... As such, you can have severe side effects from these anticholinergic drugs. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. 2. blurry vision. Antimuscarinics. Oral Tablet. Transdermal oxybutynin comes as a patch to apply to the skin. Myrbetriq (mirabegron) may cause less drowsiness, constipation, and memory loss than oxybutynin. Explore our list. -breathing problems. Ativan side effects in the elderly. The more common side effects that can occur with oxybutynin include: being unable to urinate. Yes | No . Brompheniramine, sold under the brand name Dimetapp among others, is a first-generation antihistamine drug of the propylamine (alkylamine) class. and readily penetrates the blood-brain-barrier. Other side effects not listed may also occur in some patients. Oxybutynin, like all anticholinergic medicines, can cause psychiatric side effects such as confusion, agitation, anxiety, hallucinations, nightmares, paranoia, symptoms of depression and dependence (in patients with a history of drug or substance abuse). To help you remember to apply your patches on the right days, you should mark the calendar on the back of your package of medication. Possible side effects . Ditropan (oxybutynin) may not be a good treatment option if you also have narrow-angle glaucoma. blurry vision. These side effects may go away during treatment as your body adjusts to the medicine. A second strip of liner should remain stuck to the patch. 66 Darifenacin had no significant effects on memory compared to placebo, whilst oxybutynin caused significant memory deterioration. Composite point estimates of efficacy (episodes of incontinence per 24-hour period, frequency, … In particular, oxybutynin has consistently been shown to cause deterioration in memory, the parameter considered to be the most sensitive to anticholinergic effects. PRECAUTIONS: Before using oxybutynin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies . Some of the common selective antimuscarinic drugs for bladder problems, (such as oxybutynin, darifenacin, trospium, fesoterodine, tolerodine, or solifenacin), do not routinely cause problems with medications used for dementia, but may cause anticholinergic side effects in some patients. It is available as tablets, syrup and patches 1 , 2 . 1. In addition, dextromethorphan is augments serotonin in … (5.1) Central Nervous System (CNS) effects: CNS effects have been reported with oxybutynin.If patient experiences anticholinergic CNS effects, consider dose adjustment or discontinuation of … Depending on which forum you're on they will either suggest addressing emotional issues or making healthy lifestyle changes. You can use the study as a second opinion to make health care decisions. There was little to no incidence of such side effects with patients on darifenacin, trospium, or fesoterodine. Cognitive side effects occur if the drug can cross the blood brain barrier into the central nervous system. Anticholinergic drugs block this chemical. Oxybutynin, like all anticholinergic medicines, can cause psychiatric side effects such as confusion, agitation, anxiety, hallucinations, nightmares, paranoia, symptoms of depression and dependence (in patients with a history of drug or substance abuse). You may report side effects to FDA at 1-800-FDA-1088. … This includes any possible side effects not listed in this leaflet, See section 4. ... are effective but should be prescribed carefully to older adults because of risk of memory impairment, unsteadiness, and falls. -breathing problems. To investigate the effects of darifenacin controlled-release (CR) and oxybutynin extended-release (ER) on cognitive function (particularly memory) in older subjects. Angioedema: Angioedema has been reported with oxybutynin. Atypical drugs: Avoid with QT-prolonging drugs (see above). Cholesterol-lowering drugs (Statins) Why they are prescribed: Statins are used to treat high … Tolterodine (Detrol): Basics, Side Effects & Reviews. oxybutynin, which all have known possible ocular and systemic side effects.2,3,5,10,11,13-15,17,18 Oxybutynin chloride is one of a series of acetylenic amino esters that possesses moderately potent anticholinergic, antispasmodic, and local anesthetic actions.1 It is one-tenth as potent as atropine in causing anticholinergic feeling dizzy, sleepy, or a spinning sensation (vertigo) diarrhoea or being sick (vomiting) constipation. Read more. Last updated on Oct 25, 2021. If you notice any other effects, check with your healthcare professional. The drug worked to stop the bladder spasms, but the side effects are horrible. Oxybutynin & Tolterodine Notes Indication: Side Effects: Memory Trick: Drug name: MOA: • Oxybutynin • Tolterodine Don’t get tricked with sound • Overactive bladder • Decreases urgency, frequency & nighttime bathroom visits (nocturia) • Oxy-Buty-nin - B for Bladder Ox is on your Bladder! Urinary incontinence, which is … -flushing (reddening of the skin) -hallucinations. In addition, the following adverse events were reported by 1 to < 5% of patients using oxybutynin chloride (5 to 20 mg/day) in all studies. Protect from moisture and humidity. There are other meds in the same category you can try with less side effects. Here below, Tolterodine (Detrol) is used to treat overactive bladder (OAB) symptoms such as loss of bladder control, urgency, and frequency. Anticholinergics. Posted By Anonymous in drugs.com on January 17, 2012 @ 12:00 am “ Ditropan (oxybutynin) for Overactive Bladder: While it helped with urgency it causes dry mouth and worse a loss of sexual appetite. You may report side effects to the FDA at 1-800-FDA-1088. 5. Donepezil and oxybutynin Donepezil, a reversible acetylcholinesterase inhibitor, is indicated for Alzheimer disease, but 7% of patients will develop urinary incontinence. Protect from light. Applies only to oral form of both agents. I was 26 at the time. You can use the study as a second opinion to make health care decisions. No, Gemtesa (vibegron) and Myrbetriq (mirabegron) are two different medications. The incidence of dry mouth was dose-related. Beers criteria recommend avoiding anticholinergics in pts ≥65 years, due to a risk of delirium & cognitive impairment. Oxybutynin Side Effects. This list may not describe all possible side effects. Transdermally administered oxybutynin chloride topical gel 10% (OTG) has a low propensity for anticholinergic adverse effects and possibly also a low risk of cognitive impairment. Taking Oxybutynin anti-depressant drugs may increase the side effects the patient is experiencing. It is indicated for the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing.Like the other first-generation drugs of its class, it is considered a sedating … Learn about its side effects, uses, dosage, and more. Side effects that you should report to your doctor or health care professional as soon as possible: Allergic Reactions Like Skin Rash, Itching Or Hives, Swelling Of The Face, Lips, Or Tongue. Urinary incontinence is common in patients with dementia, but it is also a side effect of memory drugs. You should not use oxybutynin if you have untreated or uncontrolled narrow-angle glaucoma, a blockage in your digestive tract (stomach or intestines), or if you are unable to urinate. Oxybutynin Side Effects Oxybutynin may cause a potentially life-threatening allergic reaction called angioedema, which requires immediate medical attention. Start my free online visit. For more information, ask your doctor or pharmacist. Thus side effects such as grogginess, drowsiness, and memory loss are common. 1. It is an agent of the antimuscarinic class and is often used in management of Parkinson's disease.It was approved by the FDA for the treatment of Parkinson's in the US in 2003.. To use the patches, follow these steps: Open the protective pouch and remove the patch. heart throbbing or pounding. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). The extended-release tablet is usually taken once a day with or without food. -confusion. Interestingly, patients who chose to be treated with oxybutynin exhibited significantly lower baseline memory performance than controls. You can use the study as a second opinion to make health care decisions. Form. RateADrug users have reported 4 Oxybutynin Chloride side effects and 1 Oxybutynin Chloride benefit. Be better informed. -flushing (reddening of the skin) -hallucinations. excessive thirst. memory impairment / Delayed / Incidence not known nystagmus / Delayed / Incidence not known ... Simeprevir, a mild intestinal CYP3A4 inhibitor, may increase the side effects of oxybutynin, which is a CYP3A4 substrate. The most common adverse events reported by patients receiving Oxybutynin chloride 5 to 20 mg/day were the expected side effects of anticholinergic agents. Even when used as instructed, anticholinergics can have some unpleasant side effects. Anticholinergic Medication. A lot of the doctors here at MedHelp don't actually advocate the use of diet pills for weight loss. Oxybutynin is used to treat overactive bladder (a condition in which the bladder muscles contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination) in certain adults and children. Monitor patients for adverse effects of oxybutynin, such as CNS and anticholinergic effects. Oxybutynin should be swallowed whole with the help of liquids. Call your doctor for medical advice about side effects. Flushing … Read the entire detailed patient monograph for Oxytrol (Oxybutynin Transdermal) dry mouth. The most common adverse events reported by patients receiving oxybutynin chloride 5 to 20 mg/day were the expected side effects of anticholinergic agents. Medscape: Please describe the rationale and design of your study comparing darifenacin and oxybutynin ER. Medically reviewed by Drugs.com. Although alternatives exist, not everyone agrees they're safer. The other drugs can worsen memory, thinking, cause excessive sedation, drowsiness and dizziness and increase your risk of falls. Breathing Problems. dry mouth. Side effects. Each oxybutynin chloride extended release tablet contains 5 mg, 10 mg, or 15 mg of oxybutynin chloride USP, formulated as a once-a-day controlled-release tablet for oral administration. Oxybutynin is an anticholinergic medicine indicated for urinary frequency and urgency. Three further studies evaluated the effects of single doses of IR oxybutynin in small numbers of subjects (Table 1) (50–52). Kay G, Crook T, Rekeda L et al. Keep out of the reach of children. Oxybutynin decreases muscle spasms of the bladder, and increases bladder capacity. oxybutynin decreases levels of risperidone by pharmacodynamic antagonism. Oxybutynin. Oxybutynin, like all anticholinergic medicines, can cause psychiatric side effects such as confusion, agitation, anxiety, hallucinations, nightmares, paranoia, symptoms of depression and dependence (in patients with a history of drug or substance abuse). antimuscarinic side-effects on cognitive function, has been neglected by urologists. Solifenacin: Same as above. These adverse effects may You may report side effects to Health Canada at 1-866-234-2345. This project aimed to study the cognitive effects of oxybutynin in children and then compare them to known deleterious effects of the drug in the elderly. Each scored biconvex, engraved blue DITROPAN® (oxybutynin chloride) Tablet contains 5 mg of oxybutynin chloride. I was on trospium chloride for awhile. for studying the potential physiological and ethological side effects of oxybutynin, including its effects on memory, social relationships and sensory perception. In an effort to reduce the side effects of oral oxybutynin, rectal suppositories and direct bladder instillation of oxybutynin have been studied. The first of these compared the acute effects of IR oxybutynin (5 or 10 mg), diphenhydramine (50 mg) and placebo on cognitive function in older adults (≥ 65 years) . This is not a complete list of side effects and others may occur. Antipsychotics. I have taken Benadryl (diphenhydramine), Paxil (paroxetine) and oxybutynin (Ditropan) for years. Oxybutynin is also sold over the counter in patch form as Oxytrol for Women. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. oxybutynin, which all have known possible ocular and systemic side effects.2,3,5,10,11,13-15,17,18 Oxybutynin chloride is one of a series of acetylenic amino esters that possesses moderately potent anticholinergic, antispasmodic, and local anesthetic actions.1 It is one-tenth as potent as atropine in causing anticholinergic Call your doctor for medical advice about side effects. I took Oxybutynin for almost a month. Other side effects include:urinary tract infection, blurred vision, dizziness, dyspepsia, headache, nausea, rhinitis, and xerophthalmia. Al though many systemic anticholinergic adverse effects (dry mouth, blurry vision, constipation, difficulty in urinating, cognitive and memory impairments) can be attributed to … Are you taking Oxybutynin Chloride? Oxybutynin chloride is administered as a racemate of R- and S- enantiomers. Trihexyphenidyl (THP, benzhexol, trihex, marketed as Artane and others) is an antispasmodic drug used to treat stiffness, tremors, spasms, and poor muscle control. Pros and cons of Myrbetriq (mirabegron) Pros. Some of the drugs include amitriptyline and nortriptyline. Causes more side effects like dry mouth than newer medications used for treating overactive bladder. Are there antidotes to anticholinergic drugs? temporary redness of face and neck. Diphenhydramine is also used for motion sickness and extrapyramidal symptoms in Parkinson’s disease patients. This group covers most over-the-counter sleeping aids, as well as a variety … The leading side effects in these studies were dry mouth, constipation, and blurred vision. Genito-urinary. Oxybutynin can cause classic anticholinergic adverse effects such as dry mouth, blurred vision, urinary retention, constipation, and confusion. Get Help. It is indicated for symptoms of urinary frequency and urgency1 that result in incontinence. farting and burping (wind) stomach pain. constipation. dizziness. Oxybutynin blocks a substance in the brain, and one of its side effects is decreased sweating … For example, the drugs may raise the risk for problems with short-term memory, reasoning and confusion … Oxybutynin blocks a substance in the brain, and one of its side effects is decreased sweating … Keep taking oxybutynin, but talk to your doctor or pharmacist if these side effects bother you or do not go away, or if you notice any other possible side effects. Cough, really bad , blurry vision, dry mouth, dry eyes, feeling like i wanted to throw up .

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